The CivilWeb Brick Calculator Excel Spreadsheet completes all these adjustments automatically, showing the required number of bricks instantly for any size masonry wall. A very economic 1 car garage can be built for as little as 10,000 12,000, whereas. Multiplying 700 square feet of wall area by 1.125 is 788, meaning you will need around 788 concrete blocks to build your garage walls. ![]() Additionally, you can determine your total concrete block cost by inputting your cost per block. You’ll generally find the cost of base work will be within the price range depending on the complexity and location of the work within the UK. This concrete block calculator allows you to estimate how many concrete blocks you'll need based on the block size and width and height of a wall. The garage base calculator can calculate costs within a range of £9 £15 per square foot of concrete laid at 4 thick (100mm). These are price estimates for simple garage spaces that will not be used as a workshop and don’t have any special plumbing or electric wiring. VAT will depend on whether or not the builder is VAT registered. ![]() Stamped concrete costs 9-23 per square foot, depending on the design complexity. The biggest 12x816 CMU blocks cost 2 to 4 per block. ![]() Standard 8x8x16 concrete block prices are 1.25 to 2.50 each. The cost ranges between 19,600 and 28,200. Building and construction concrete block prices are 1 to 4 per block, depending on the size. This is not always as simple as it may seem, the calculation needs to be adjusted for brick size, mortar depth and for brick cuts. The national average cost of building a new 2 car garage is 23,900. One of the first calculations to undertake when planning a masonry project is to determine exactly how many bricks, mortar and other materials will be required. The Concrete Calculator estimates the volume and weight of concrete necessary to cover a given area.
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HQ461 was identified through phenotype-based high-throughput small-molecule screening and found to possess potent cytotoxicity. In this study, we report the discovery and the mechanism of action of a new molecular glue HQ461. However, the rarity of molecular glues has limited their potential as a general strategy for drug development. For example, the compactness of the thalidomide scaffold allowed the development of bivalent proteolysis targeting chimeras to direct cereblon to degrade disease-relevant proteins ( Lu et al., 2015 Winter et al., 2015). Third, molecular glues possess favorable pharmacological properties to serve as drug candidates. Second, molecular glues can target transcription factors and splicing factors, by recognizing either relatively flat surfaces or disordered regions of these proteins ( Han et al., 2017 Krönke et al., 2014 Lu et al., 2014 Tan et al., 2007). Such unique binding characteristics can be explained by induced protein-protein interactions and pre-existing protein surface complementarity as revealed by structural analysis of molecular glue-bound protein complexes ( Bussiere et al., 2020 Du et al., 2019 Faust et al., 2020 Tan et al., 2007). First, molecular glues often bind to their target proteins with modest or even undetectable affinities, while enhanced affinities are usually observed once a regulatory protein is also present in the system ( Bussiere et al., 2020 Du et al., 2019 Faust et al., 2020). Several common themes have emerged from this limited set of molecular glues. More recently, indisulam and related anticancer sulfonamides were discovered to function by promoting the interaction between the splicing factor RBM39 and the E3 ubiquitin ligase DCAF15, resulting in the degradation of RBM39 to cause aberrant pre-mRNA splicing ( Han et al., 2017 Uehara et al., 2017). Similarly, the thalidomide class of immunomodulatory drugs binds to the E3 ubiquitin ligase cereblon and alters its substrate specificity to recognize and degrade several zinc finger transcription factors ( Ito et al., 2010 Krönke et al., 2014 Lu et al., 2014). For example, macrocyclic natural products cyclosporin A, FK506, and rapamycin recruit FKBP proteins to the phosphatase calcineurin or the kinase mTORC1, interfering with their enzymatic activities to control intracellular signal transduction ( Brown et al., 1994 Liu et al., 1991 Sabatini et al., 1994). Notwithstanding, molecular glues are rare and were discovered serendipitously only a handful of molecular glues have been documented over the past four decades. As a result, molecular glues have been viewed enthusiastically as a unique pharmacological modality to target proteins without druggable pockets ( Maniaci and Ciulli, 2019). Unlike conventional small molecules that bind to active sites or allosteric sites to modulate the activity of their target proteins, molecular glues influence the activity or fate of their target proteins by bringing them to the vicinity of regulatory proteins. ![]() ![]() The name ‘molecular glue’ was first coined to describe the mechanism of action of the plant hormone auxin, which bridges an interaction between the E3 ubiquitin ligase TIR1 and IAA transcription repressors, leading to IAA destruction by the ubiquitin-proteasome system to activate auxin-response gene expression ( Tan et al., 2007). Molecular glues are a class of small molecules that induce the formation of protein-protein interactions to elicit biologic or therapeutic effects. Our studies reveal a new molecular glue that recruits its target protein directly to DDB1 to bypass the requirement of a substrate-specific receptor, presenting a new strategy for targeted protein degradation. Structure-activity relationship analysis of HQ461 revealed the importance of a 5-methylthiazol-2-amine pharmacophore and resulted in an HQ461 derivate with improved potency. Degradation of CCNK mediated by HQ461 compromised CDK12 function, leading to reduced phosphorylation of a CDK12 substrate, downregulation of DNA damage response genes, and cell death. Using loss-of-function and gain-of-function genetic screening in human cancer cells followed by biochemical reconstitution, we show that HQ461 acts by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK). Here, we report a new molecular glue HQ461 discovered by high-throughput screening. ![]() Molecular-glue degraders mediate interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation. ![]() The project plan also includes establishing baselines or performance measures. It involves identifying the cost, quality, available resources, and a realistic timetable. Refinable – As new situations arise, be flexible and refine goals as needed.ĭuring this phase, the scope of the project is defined and a project management plan is developed. This can optimize the quality of work.Īppreciable – Break larger goals into smaller tasks that can be quickly achieved. Limited – They should be limited in scope and time to keep it manageable.Įmotional – Goals should tap into the passion of employees and be something they can form an emotional connection to. Goals – A newer method for setting goals that takes into consideration the environment of today’s fast-paced businesses.Ĭollaborative – The goal should encourage employees to work together. goal templates, read " The Essential Guide to Writing S.M.A.R.T. Timely – Create a timeframe to achieve the goal.įor more information about S.M.A.R.T. ![]() Realistic – You should be willing and able to work toward a particular goal. Measurable – Create criteria that you can use to measure the success of a goal.Īttainable – Identify the most important goals and what it will take to achieve them. Specific – To set specific goals, answer the following questions: who, what, where, when, which, and why. ![]() It also provides a way to clearly understand the implications of the goal-setting process. Goals – This method helps ensure that the goals have been thoroughly vetted. It is up to PMPs to apply the techniques and phases covered in the PMBOK ® Guide to the unique requirements of their project. The PMBOK ® Guide includes a process standard that can be applied to many projects however, it does recognize that each project is different. ![]() In an effort to standardize project management information and practices, a team of over 80 PMI members created the text, A Guide to the Project Management Book of Knowledge (PMBOK ® Guide) Currently in its fifth edition, the PMBOK ® Guide is continually being updated by the PMI and shares the fundamental best practices that are used worldwide to achieve the best results. There are seven other certifications available for different types of project management. The gold standard of certification from the association is the Project Management Professional (PMP) ® certification. It has set the standards for project, program, and portfolio management and offers training and certifications. PMI, which began in 1969, is the world’s largest nonprofit membership association for the project management profession. In this article, we’ll cover what each of these phases entail and share tips for boosting success during each stage.ĭeveloped by the Project Management Institute (PMI), the five phases of project management include conception and initiation, project planning, project execution, performance/monitoring, and project close. There is a science to what they do - they have a deep understanding of and can perfectly execute the five phases of project management. While some people think a project manager’s sole job is to remind everyone about deadlines and set up status meeting, that’s simply not the case. Getting started with the Smartsheet APIĪt the root of any successful project is a project manager (PM) worth his or her weight in gold.ENGAGE Smartsheet ENGAGE brings together our global customers, experts, and partners to share their experiences, ideas, and best practices.Smartsheet events Your hub for Smartsheet events, webinars, Q&As, and user groups.Partners Learn about the Smartsheet partner program and access our partner directory.Community Explore user-generated content and stay updated on our latest product features.Help and Learning A comprehensive knowledge base, including articles, tutorials, videos, and other resources that cover a range of topics related to using Smartsheet.Content Center Articles and guides about project management, collaboration, automation, and other topics to help you make the most of the Smartsheet platform. ![]() Not only that, but, like Tinder, OKCupid is also owned by Match Group. No doubt you'll have heard of OKCupid, and that's because it's another longtime player in the online dating world. Best for: Seeing how compatible potential partners are.While we've yet to hear of a success story from this app (not to say that they aren't out there), if there's one thing Thursday can do, it's help focus your time and stop the ceaseless scrolling, while also attending some fun events. Going live only on, you guessed it, Thursdays, you have 24 hours to either match with other people in your area and organise a date - or attend one of the weekly events to meet a bunch of people at once. If you're trying to minimise the amount of time you're spending endlessly scrolling through dating apps, it might be time to switch to this, Sarah* reckons. If nothing has transpired within that window? The match will either disappear forever or roll back around next Thursday when you could always revisit the vibe. Every Thursday, it allows you to make a maximum of ten matches and arrange a date for that evening (or, if you're feeling rebellious, the next). Resigned to the ubiquity of technology but sick of doing all your dating online? Thursday is for you. I guess the key to her heart was, er, Hinge. Anecdotally, it’s also one of the best to bag a long-term partner, which Brit can attest to, having met her boyfriend on the app back in 2019. You can find out who’s funny, charming, and who, by way of refusing to join in with the prompts, has no personality. Already inherently cringe by nature (trying to sell yourself to potential dates? Horrible!), a dating app that requires personality is a daunting prospect – but that’s exactly why it’s one of the best. When Hinge swelled in popularity, back in around 2018, users – including Brit – were sceptical about its format, specifically the requirement to answer three prompts, like, ‘They key to my heart is.’. ![]() Since it favours all-rounders and offers most of its features for free, it's a spectacular alternative to the hook-up culture on Tinder. The smartest part? You can match with someone by liking a reply they've made to a prompt rather than simply showing appreciation for a picture. Now, it's one of the most popular dating apps out there, mostly due to its healthy balance of photos and personal details. Since it once allowed users to meet friends of friends, Hinge began as the virtual equivalent to a wedding. Best for: Swiping on personalities, not just looks.You can send flirts, likes and virtual gifts, but if you want to chat with potential matches (and we presume you will), you'll have to pay. ![]() Simple to use, OurTime is as classic as the people who use it: all you'll need to do is make a simple profile complete with picture and you'll be able to see local members or search for people OurTime suggests. What it lacks in sophisticated matchmaking tech, it makes up for in its engaged community who won't just swipe right for anyone, you know. A simple app that provides safe online chat features to arrange real-life meet-ups, OurTime eschews rigorous personality tests and algorithms in place of pairings based on shared interests, location and search criteria. While most dating apps won‘t discriminate against older profiles, OurTime provides a dedicated platform for those seeking a more mature partner who is swimming in the over-50s dating pool.
![]() As these two writing systems evolved, Anglo-Saxon Futhorc runes emerged among the Germanic tribes that had migrated toward what is now modern-day England. Next came the Younger Futhark runes, which lasted from 800-1100 AD. The 3rd aett is ruled by Tyr and Ziza.Įlder Futhark runes were used until about 800 AD. ![]() The 2nd aett is ruled by Mordgud and Hagalaz (Heimdall). The first aett is ruled by twins Freyr and Freya. The 24 runes are divided into 3 groups of 8 known as aetts.Īett is Old Norse for “family.” Each family of runes is attributed to gods. The Elder Futhark runic alphabet has 24 symbols, each with its own meaning. What are Elder Futhark Runes?Įlder Futhark runes are the first known rune-writing system. It is believed that Odin revealed runes to the first human rune-master. Their meaning remained a mystery in Norse mythology until Odin’s ritual sacrifice of his own life revealed their meaning to him. In the Viking age, warriors would carve runes into their weapons in hopes of making them more powerful and accurate.Įven the world tree Yggdrasil had runes engraved in its trunk. Runes held magical powers, including making Odin’s spear Gungnir hit its mark every time, no matter who threw it. In Old Norse Mythology, runes were so important that Odin hung himself from the world tree Yggdrasil for nine days and nights just to learn their secrets. ![]() Outside of the literal translation, the meaning could be intuited by a rune-master based on the context and placement of the rune.įor example, Fehu (ᚠ) means “cattle.” This symbol could also be interpreted as wealth or abundance since having cattle was a sign of wealth during the Viking age. Like hieroglyphics, pictographs, and even the Native American petroglyphs, the runic alphabet represented specific elements, animals, or gods. Since the runic symbols represented things such as a horse, water, or a Norse god, their meaning was universal in Scandinavia. While the runic alphabet remained pretty similar for centuries, each Germanic tribe that used the runes did so in their native language. Old Norse runes were written in the Proto-Norse language. What language are Viking runes (Old Norse runes) written in? On stone, long-branch was often preferred, while short-twig was best for wood carvings. The writing medium also influenced which style was used. Sweden and Norway tended to stick with shorter lines, called short-twig form. In Denmark, runic symbols were written with longer lines, known as long-branch form. As the use of the runic alphabet spread, their written form was adapted. Runes are the earliest known writing system of the Germanic people’s language. The Kylver runestone from Gotland, Sweden ![]() The many problems BB3 had in both multiplayer and singleplayer are galling because it's still quite fun when it works. I've seen it freeze while trying to figure out whether to follow up after smacking a ball-carrier, waiting until both the turn timer and a full 7.30 minutes of bonus time runs down before the match continues. But when it doesn't, when a pass is intercepted by someone nowhere near it, or when you realize basic features like crossplay and the special rules for star players are being saved for Season 3, it's impossible to keep faith in.es paused for long stretches while deciding what to do next. The many problems BB3 had in both multiplayer and singleplayer ware galling because it's still quite fun when it works. It launched with features missing, but had a roadmap for three seasons' worth of battle passes and a modestly well-stocked in-game cosmetics shop. Warhammer Quest 2: The End Times (2019)Ĭyanide's third attempt at Blood Bowl was hobbled by the 2020s trend of making everything a live-service game with seasonal content. It falls in the same barren middle ground between the epic scale of Dawn of War and the intimate squad tactics of Dawn of War 2, and it's galling to see another Warhammer game repeat the same mistake. ![]() The end result is a mish-mash of too much and not enough, which is exactly the same problem Dawn of War 3 had. There's a rock-paper-scissors element to the combat system, but engaging with it in larger levels is a distraction too far. Of course, the more troops you have the harder it is to use them intelligently rather than shuffling them around like blobs. Meanwhile, you need to bounce between battles on multiple fronts because the enemy is attacking your muster point while you're trying to push back the fog of war to find your objectives and also churn out enough troops to keep up with the escalation. It doesn't help that the controls feel sticky and clumsy. You have to micromanage some of your units because they've got fussy abilities like Charge, which can valuably stun opponents, but having to line that up in real-time means taking attention away from other units, like your ranged troops who refuse to shoot outside their firing arc and will get attacked from behind if you don't pay attention to them too. Warhammer Quest: Silver Tower (2021)Īn RTS that sets the Stormcast Eternals up against Disciples of Tzeentch, Orruk Kruleboyz, and Nighthaunt, Realms of Ruin suffers from a familiar problem of scale. Bugs and floaty controls may be fixable, but how boring Tempestfall is? Probably not. Get past them and you'll find batches of samey skeletons and ghosts appearing in designated combat arenas, which are separated by designated exploration zones with glowing collectibles and NPCs stiffly waving their arms while droning exposition. It's a bit janky all over, with doors getting stuck halfway and the bits where you squeeze through a tight passage or climb down a rope occasionally glitching you off into space. Those weapons lack heft though, making combat feel like you're waving a Wiimote rather than a magic axe. You summon weapons-sword, axe, and staff-by gripping your fists, cast spells by squeezing a trigger while waving, sweeping, and pointing them, and then go to town on the undead of the Nighthaunt. A VR action game where you're a lord-arcanum of the Stormcast Eternals, basically a lightning wizard in heavy armor. Fixed Horse, Donkey & variants’ animation speed when ridden for 1.19.4.Fixed Villager ‘nope’ action when riding or swimming. ![]() ![]()
![]() The first Fighters Pass includes Challenger Packs 1 - 5, while Fighters Pass Vol. Steve and Alex have several unique abilities, such as. During a presentation ahead of Minecraft Live, Director Masahiro Sakurai talked in depth about what Minecraft Steve and Alex are bringing to Super Smash Bros. Four more fighters remain in the second Fighters Pass. 2 are not included as part of the Fighters Pass. Minecraft Steve and Alex have a release date of October 13, 2020. 2, and the fighters in Fighters Pass Vol. Please note: the fighters in the Fighters Pass are not included as part of Fighters Pass Vol. *All Challenger Packs from Fighters Pass Vol. You can also get updates by following on Twitter. Ultimate gamepage, or by joining our Smash Bros. Just earlier this year, he enchanted audiences as Bowser in The Super Mario Bros. On October 1st, 2020, Steve was revealed to be the fighter included in Challenger Pack 7, with more information revealed two days later, prior to. ![]() Stay up to date on everything about Super Smash Bros. Minecraft will mark Jack Black’s third video game movie of the decade. 2 is available now and will grant access to Challenger Pack 7: Steve & Alex from October 14th, in addition to four yet-to-be-announced Challenger Packs, each including one new fighter, one stage and multiple music tracks. This set also includes the Minecraft World stage, a Classic Mode route, a DLC Spirit Board, and seven music tracks from the Minecraft series.įighters Pass Vol. Challenger Pack 7: Steve & Alex will be released on October 14th, both as part of Super Smash Bros. ![]() So far I have an Arduino Mega 2560 connected to a 32圆4 LED Matrix and a VS1053 MP3 player. I have a lot of cards that I use for testing SdFat and many fail in this module. The voltage on the pins will be limited by the current the Arduino pins can supply. ![]() Giktechnology 17.6.21 Input and Output Each of the 54 digital pins on the Arduino 2560 Mega can be used as an input or output, using pinMode (), digitalWrite (), and digitalRead () functions. It will cause your card to draw excess current since the Arduino tries to drive CS, MOSI, and SCK with 5V. I am hitting a roadblock trying to understand SPI master slave configurations. SPI PIN ON THE ARDUINO 2560 MEGA MISO MOSI SCK SS. I for the life of me cannot figure out how to either output their respective signals on two pins or share one somehow. Before using this example, wire an EEPROM to the SPI pins on your Arduino as described: SPI EEPROM Pins, Arduino Pins. DIYmalls 1.44 inch SPI TFT LCD Display Screen Module 128x128 ST7735S 5V/3.3V 11 Pin Version for Arduino U NO Mega-2560 (Pack of 2) Size, 2.8 inch Resolution. After this article, you will learn how to use the SPI protocol and read/write data via the SPI protocol. I have also included Arduino SPI read example with the RFID-RC522 reader. I also have an altimeter connected (working fine) and an LCD display (from the Arduino starter kit) which uses SPI. I have included a detailed specification, pin diagram, and code for SPI communication between two Arduino boards. The SPI pins are also broken out on the ICSP header, which is physically compatible with the Uno. Hello! I am working on a project that has two devices each with their own CLK pins. I have an Arduino Mega 2560 Rev3 stacked with a Gravity Expansion shield by DF Robot, which has a built in micro SD module. These pins support SPI communication using the SPI library. The late Curtis Mayfield was one of American soul’s finest singers, songwriters, and producers. put it, “I don’t know if I want to get too far off the path - I don’t want to get lost in the forest - but I like to wander out a bit and adventure.” We also tended to give an edge to artists who channeled whatever gifts god gave them into great songs and game-changing albums, not just impressive playing.Īs modern blues visionary Gary Clark Jr. In making the list, we tended to value heaviness over tastiness, feel over polish, invention over refinement, risk-takers and originators more than technicians. ![]() (All you Balalaika shredders out there, keep at it maybe next time.) Our only instrumental criteria is that you had to be a six-string player. Many great guitarists realized their genius as part of a duo, so Kim and Kelley Deal of the Breeders, Adrian Smith and Dave Murray of Iron Maiden, and other symbiotic pairs share an entry. There are huge stars like Prince, Joni Mitchell, and Neil Young, and behind-the-scenes masters like Memphis soul great Teenie Hodges and smooth-rock assassin Larry Carlton. There are peerless virtuosos like Pat Metheny, Yvette Young, and Steve Vai, as well as primitivists like Johnny Ramone and Poison Ivy of the Cramps. The list has rock, jazz, reggae, country, folk, blues, punk, metal, disco, funk, bossa nova, bachata, Congolese rumba, flamenco, and much more. The earliest entrant on the list (folk music icon Elizabeth Cotten) was born in 1893, the youngest (indie-rock prodigy Lindsey Jordan) was born in 1999. We wanted to show the scope of the guitar’s evolution. But mythic guitar gods like Jimmy Page, Brian May, and Eddie Van Halen are only one part of the story. Guitar players are often as iconic as the lead singers for the bands they play in. Our new expanded list was made by the editors and writers of Rolling Stone. It was compiled by a panel of musicians, mostly older classic rockers. ![]() Rolling Stone published its original list of the 100 Greatest Guitarists in 2011. That’s why thinking about what makes a great guitarist is so much fun. ![]() Anybody can pick up a little guitar in no time at all, but you can spend a lifetime exploring its possibilities. It is who I am.” The guitar is the most universal instrument, the most primal, and the most expressive. “My guitar is not a thing,” Joan Jett once said. |
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